KMID : 0366220140490030148
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Korean Journal of Hematology 2014 Volume.49 No. 3 p.148 ~ p.153
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Serum beta-2 microglobulin in malignant lymphomas: an old but powerful prognostic factor
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Yoo Chang-Hoon
Yoon Dok-Hyun Suh Cheol-Won
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Abstract
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Beta-2 microglobulin is synthesized in all nucleated cells and forms the light chain subunit of the major histocompatibility complex class I antigen. Despite its potential role as a convenient and non-invasive prognostic indicator in malignant lymphomas, the influence of serum ¥â2 microglobulin is currently underestimated, and therapeutic decision making
is rarely affected by this marker. Recent studies that included relatively large numbers of patients with specific histologic subtypes showed that serum ¥â2 microglobulin is a potent prognostic marker in malignant lymphomas. In follicular lymphoma, this effort led to the incorporation of serum ¥â2 microglobulin as an indicator in a new prognostic model.
In this review, we summarize the current evidence supporting the role of serum ¥â2 microglobulin as a prognostic factor in patients with malignant lymphoma and discuss perspectives for future investigations.
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KEYWORD
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Beta-2 microglobulin, Lymphoma, Prognostic factor
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